Selenium the Se-XY Nutraceutical
Written by Ben Bunting: BA(Hons), PGCert.
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What is Selenium?
Selenium is a trace mineral that can be found in various foods. Its concentration in foods varies depending on the soil and water used to grow them. You can also get selenium from food supplements or multivitamins. However, it's important to know the recommended daily allowance of selenium to avoid toxicity. Selenium is thought to be beneficial for a variety of health issues, but researchers are still conducting clinical studies to find out its exact role in human health.
Biological functions
Selenium, or Se, is an essential trace element with a very narrow margin between its beneficial and toxic effects. In humans, selenium chemopreventive effects are attributed to the antioxidant action of selenoproteins. It is also implicated in the upregulation of phase 2 enzymes. One of the most effective selenocompounds is se-methylselenocysteine, a naturally occurring organic Se product.
Selenium is involved in maintaining body health through its ability to regulate immune regulation and oxidative stress. It is absorbed in the body as a soluble form called selenoproteins. These selenoproteins have multiple biological functions, including regulating the immune system and regulating cellular proliferation. These proteins include GPX1 and GPX2, which regulate the body's production of reactive oxygen species. DIO1, a selenoprotein that regulates the metabolism of thyroid hormones, plays a role in epithelial stem-cell function, and has a potential to prevent the growth of cancer cells.
Selenium also plays an important role in regulating inflammatory responses. It is also involved in neutralising the effects of free radicals. The selenoproteins combined with glutathione peroxidase function in the body, reducing oxidative stress.
Besides being an essential trace element, selenium has numerous biological functions, including the regulation of thyroid hormones, growth and differentiation. It is also necessary for proper brain and immune system functions. In addition, selenium helps regulate the inflammatory response in the body.
Besides its role in regulating inflammatory responses, selenium is also a potent anti-cancer agent. Its organic forms include methylselenic acid, selenoacid derivatives, selenoesters, and selenoaminoacids. Each form of selenium has a different mechanism of action.
Mechanisms of action
Selenium the Se-XY nutraceutical consists of two active compounds that promote metabolism. The first compound is selenomethionine, a precursor to selenoproteins. It is metabolized to selenocysteine through a pathway called transsulphation. The second compound is selenophosphate, produced by selenophosphate synthase.
Selenium is essential for immune function and holds a unique place in human metabolism. In addition to its ability to inhibit inflammatory cytokines, it regulates thyroid function and enhances male fertility. It is also a potent anti-oxidant and promotes wound healing.
Selenium occurs naturally in two forms: organic and inorganic. Organic forms are found in the body while inorganic forms accumulate in plants. Both forms have antioxidant, anti-inflammatory, and anti-mutagenic properties. Selenium is the 67th most abundant element in the earth's crust.
Organic selenium compounds are metabolized differently from inorganic forms and are more easily absorbed in the human body. Selenium is also known to inhibit cancer growth and prevent tumors. There are numerous publications to support the benefits of dietary selenium. However, toxicity is a concern.
Selenium the Se-XY nutraceutical is a highly effective anti-cancer supplement. Its anti-inflammatory and anti-cancer properties are attributed to its ability to inhibit solid tumors. Organic selenium compounds have been shown to inhibit cell growth in a variety of cancer cell lines, including lung cells. The latter were particularly sensitive to selenite.
Selenium is an important element for plant growth and protection against oxidative stress. It also has a role in phytoremediation and biofortification. Based on selenium accumulation, plants are categorized into two types: hyper-accumulators and hypo-accumulators. Se-tolerant and hypo-accumulators are those that do not accumulate selenium in their soil.
Safety
In order to understand the safety of Selenium the Se-XY-nutritional supplement, you need to understand what this product is capable of. It is a mineral with anti-oxidant and anti-proliferative properties. It is known to reduce the risk of oxidative stress and cancer, as well as to boost immune system function. Furthermore, it is known to improve the quality of cells and DNA.
Selenium is considered to be safe to use in dosages as low as 45 mcg daily for infants. It is also safe for use during pregnancy and breast-feeding, though selenium at higher doses may have adverse effects on the unborn child. Furthermore, selenium may stimulate the immune system and aggravate autoimmune diseases, so you should avoid taking selenium supplements if you have these conditions.
Although selenium is essential for human health, a deficiency or excessive intake can lead to health problems. Selenium levels in the blood vary greatly, and different regions and population have different levels of selenium. A recent study in China was conducted to define an age-specific reference interval for selenium levels. The study used inductively coupled plasma mass spectrometry to determine total blood selenium levels in Chinese adults.
Safety of Selenium the Se-X-Y nutraceutical (Se-XY) has been studied in critically ill patients. A study involving intensive care showed that selenium supplementation decreased the risk of mortality by more than half after a week. It also improved VAP and reduced the incidence of pneumonia after ICU discharge.
The selenium XY nutraceutical was formulated to increase bioavailability, stability, and bioactivity. It is available in nanoforms that exhibit high bioavailability and low toxicity.
Sources
Selenium is one of the most essential micronutrients for human beings. It is found in plants and animals through the sulphur assimilation pathway, and humans consume it through dietary supplements. The amount of selenium in different plant species and soils varies. In the Indian subcontinent, selenium levels are much lower than those found in European soils. A daily dietary intake of selenium is therefore essential for maintaining homeostasis and natural metabolism.
Selenium comes in two forms: inorganic and organic. The organic form is present in the human body, and the inorganic form is accumulated in plants through the soil. Both forms combine with other elements, and selenium ranks as the 67th most abundant element in the earth's crust.
Selenium is an essential trace element that supports human metabolism and immune function. It is found in organic forms called selenoproteins, which possess unique translational and synthesis coding. These proteins play a significant role in regulating human metabolism and anti-inflammatory actions. They act as oxidative stress-reducing enzymes, regulating inflammatory cytokines and promoting homeostasis.
The recommended dietary allowance for adults is 55 ug (0.7 umol) per day. Inadequate intakes can cause selenium toxicity. In addition, excessive amounts can lead to selenium deficiency-related illnesses. In fact, some studies have suggested that the safe amount of selenium for humans is lower than expected.
Se-Yeast and edible mushrooms are excellent sources of selenium and are also an effective way to create selenium-enriched food supplements. These mushrooms are rich in nutrients and have been biofortified with the essential trace element. Biofortification of mushrooms can help meet the growing demand for Se in humans. Mushrooms can turn selenium into organic forms, and they incorporate selenium into protein-active macromolecules during metabolism. Inorganic selenium is found in skeletal muscle, where it occupies a significant portion of the body's total selenium pool. Several researches have indicated that selenium enhances the function of several enzymes. In addition to serving as a bionutrient, selenium has anti-cancer and anti-inflammatory functions.
Pharmacology
Selenium is a trace element essential for humans, with antioxidant and immunologic functions. Its biological activity is mediated by selenioproteins. These selenioproteins contain selenium in stoichiometric amounts at active sites and have catalytic redox activity. Selenium contributes to the detoxification of peroxides in living cells. It is a key micronutrient, and deficiencies are associated with a variety of symptoms.
Pharmacologic studies have demonstrated that selenium contributes to normal pulmonary function, including in patients with severe lung disease. Moreover, selenium is thought to play an important role in male fertility and is a potent antioxidant. One clinical study found that supplementation with selenium reduces the severity of pneumonia and reduces the severity of illness in critically ill patients.
The use of high-dose parenteral selenium has been associated with reduced mortality. It is also considered the cornerstone of antioxidant defense in SIRS patients. Numerous clinical studies have evaluated selenium alone and in combination with other micronutrients. Nevertheless, the results have been inconsistent. This is because the pharmacokinetics of the transient prooxidant effect of the bolus has not been completely understood. On the other hand, continuous selenium infusion has proven to be effective and well-tolerated.
Se is also important for immune function and provides the body with the ability to resist viral infections. It also plays a role in redox homeostasis and antioxidant functions. In fact, selenium deficiency is linked to impaired immune function. Inadequate levels of Se lead to increased oxidative stress in the body. It may also lead to alteration of viral genomes. Nevertheless, studies have shown that selenium supplementation improves immunity to H1N1 influenza virus and COVID-19 virus infection.
Conclusion
Selenium is a micronutrient that is important for life. Its lack in the diet has been associated with infertility and various human diseases. However, dietary selenium intake and processing are not well understood. This uncertainty leads to imprecision in dietary guidelines and adverse outcomes.
Selenium is a vital mineral that regulates cellular responses to oxidative stress. It enhances the endogenous antioxidative defence system by increasing glutathion peroxidase activity, which reduces the production of reactive oxygen species. The formation of these reactive oxygen species is dangerous because they damage cellular membranes.
One study showed that women who took dietary supplements of selenium during their pregnancy had a lower risk of postpartum depression. This was true even for women who had previous severe episodes of depression. The researchers concluded that selenium could be used as a marker to detect people at risk for depression in the future. That would enable earlier treatment.
Research on selenium has been gaining momentum in recent years. Researchers are examining selenium's role in various disorders. A growing body of evidence suggests that low selenium levels are linked to increased occurrence of depression, phobic states, and hostility in interpersonal relationships. This mineral is found in the body as a selenoprotein and is present in the form of selenocysteine amino acid.
